Neurogenic Inflammation, Chronic Pain & Nerve Regulation

Perineural Therapy is a specialized medical treatment designed to reduce neurogenic inflammation and restore normal function in superficial sensory nerves. This therapy is commonly used in integrative and regenerative medicine to address chronic pain, hypersensitivity, and nerve-related dysfunction at their neurological origin.

At Inman Clinic, Perineural Therapy is applied as a precision-based intervention focused on calming irritated nerves and restoring proper neuroimmune balance—rather than masking symptoms.

What Is Perineural Therapy?

Perineural Therapy is a medical technique that involves injecting very small amounts of solution (commonly low-dose dextrose) just beneath the skin, directly over superficial sensory nerves.

Unlike traditional injections aimed at joints or muscles, Perineural Therapy targets the small cutaneous nerves responsible for transmitting pain and inflammatory signals.

This approach is particularly effective in conditions driven by neurogenic inflammation, where irritated nerves continuously release inflammatory mediators that sustain chronic pain and tissue dysfunction.

Clinical Explanation

Superficial sensory nerves contain specialized receptors that regulate pain and inflammation signaling. When these nerves become chronically irritated—due to injury, repetitive stress, inflammation, or metabolic dysfunction—they may remain in a hyper-excitable state.

This leads to:

• Persistent pain or burning sensations
  
• Local swelling or hypersensitivity
  
• Radiating or unexplained discomfort
  
• Reduced tissue healing
  

Perineural Therapy helps stabilize nerve membranes, reduce inflammatory signaling, and restore normal nerve function at the skin–nerve interface.

How Does Perineural Therapy Work?

Perineural Therapy works through targeted neuroimmune modulation.

The treatment may help:

• Calm irritated sensory nerves
  
• Reduce neurogenic inflammation
  
• Improve nerve signaling and tissue tolerance
  
• Decrease chronic pain sensitivity
  
• Support local blood flow and healing
  

Injections are superficial, use very small volumes, and are typically well tolerated with minimal discomfort.

Potential Physiological Effects

Clinical experience and integrative medical literature suggest that Perineural Therapy may support:

• Reduction of chronic and neuropathic pain
  
• Decreased burning, tingling, or hypersensitivity
  
• Improved nerve function and tolerance to movement
  
• Reduction of localized inflammation
  
• Improved tissue recovery in chronic pain conditions
  

Rather than acting as an anesthetic, the therapy promotes nerve normalization and regulation.

Clinical Applications

Perineural Therapy may be incorporated into treatment protocols for:

• Chronic musculoskeletal pain
  
• Tendinopathies and overuse injuries
  
• Neuropathic or nerve-related pain
  
• Post-surgical nerve irritation
  
• Headaches and facial pain
  
• Scar-related pain or hypersensitivity
  
• Chronic inflammatory pain syndromes
  

It is often combined with Neural Therapy, regenerative injections, NESA neuromodulation, IV therapy, and functional medicine approaches.

Who May Benefit from Perineural Therapy?

Perineural Therapy may be appropriate for individuals experiencing:

• Persistent localized pain or hypersensitivity
  
• Nerve-related pain without clear structural damage
  
• Chronic pain that has not responded to conventional treatments
  
• Burning, tingling, or sharp pain patterns
  
• Pain related to scars or superficial nerve irritation
  

All treatments are preceded by a medical evaluation to ensure appropriate patient selection.

Safety Profile

When performed by a trained medical professional, Perineural Therapy is considered safe and minimally invasive.

Safety considerations include:

• Medical screening prior to treatment
  
• Use of low-risk, biocompatible solutions
  
• Avoidance in cases of active infection at injection sites
  

Temporary redness or mild soreness at injection sites may occur and typically resolves quickly.

Frequently Asked Questions (FAQ)

Is Perineural Therapy the same as prolotherapy?

No. While both may use dextrose, Perineural Therapy targets superficial sensory nerves, not ligaments or joints.

Is this treatment painful?

Discomfort is usually minimal, as injections are shallow and use very small volumes.

How many sessions are required?

The number of sessions varies depending on the condition and individual response.

Can Perineural Therapy be combined with other treatments?

Yes. It integrates well with Neural Therapy, NESA neuromodulation, EMDR, regenerative medicine, and IV therapy.

Perineural Therapy at Inman Clinic

At Inman Clinic, Perineural Therapy is part of an integrative medical model focused on nervous system regulation, inflammation control, and long-term recovery.

Our approach emphasizes precision, safety, and individualized treatment—addressing neurogenic inflammation at its source.

👉 Schedule a consultation to determine whether Perineural Therapy may be appropriate for your condition and health goals.